OBJECTIVE： To investigate the effects of atorvastatin combined with valsartan on efficacy， safety and related indicators in patients with chronic nephritis. METHODS： 86 patients with chronic nephritis were randomly divided into control group  （43 cases） and observation group （43 cases）. All patients were given low-salt， low-protein and high-quality diet with protein intake of 0.8 g/（kg·d）， appropriately given Cyclophosphamide tablet， Prednisone tablet， Penicillin V potassium tablet and other conventional treatment. Based on it， control group was given 160 mg valsartan， once a day in early morning. Observation group was additionally given 20 mg atorvastatin， once a day before bedtime. They were treated for 6 months. Clinical efficacy， 24 h protein amount （24 h pro）， serum creatinine （Scr）， blood urea nitrogen （BUN）， glomerular filtration rate （GFR）， C-reactive protein （CRP）， total cholesterol （TC）， triglyceride （TG ）， low density lipoprotein （LDL） and high density lipoprotein （HDL） in 2 groups were observed， and incidence of adverse reactions was followed-up for 9 months. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）. Before treatment， there were no significant differences in 24 h pro， Scr， BUN， GFR， CRP， TC， TG， LDL and HDL between 2 groups （P＞0.05）. After treatment， 24 h pro， Scr， BUN and CRP in 2 groups were significantly lower than before， and observation group was lower than control group， GFR was significantly higher than before， and observation group was higher than control group， the differences were statistically significant （P＜0.05）. TC and LDL in 2 groups were significantly lower than before， HDL was higher than before， the differences were statistically significant （P＜0.05）； but there were no significant differences in the TG between 2 groups and before and after treatment （P＞0.05）. And there was no significant differences in the incidence of adverse reactions between 2 groups （P＞0.05）. CONCLUSIONS： Based on the conventional treatment， the efficacy of atorvastatin combined with valsartan is superior to valsartan alone in the treatment of chronic nephritis， and it can significantly improve renal functions， with similar short-term safety.