OBJECTIVE：To evaluate the quality of Simvastatin tablet from different manufacturers in 10 provinces by determining their dissolution. METHODS： Referring to Japan Drug Quality Reevaluation Project， water， pH 1.2 Hydrochloric acid solution， pH 4.0 Acetate buffer solution and pH 6.8 Phosphate buffer solution （containing 0.5％ sodium dodecyl sulfate） were used as dissolution media to incestigate the dissolution of original and different domestic preparations， and f2 factor method was conducted to investigate the similarity of dissolution between 10 kinds of Simvastatin tablet and original preparations. RESULTS：The f2 of Simvastatin tablet from most of those manufacturers in 10 provinces were less than 50， and the dissolution and original preparations were dissimilar. CONCLUSIONS：The domestic Simvastatin tablet shows significant difference with original preparations， and the quality standard of generic-made need to be further improved.