OBJECTIVE：To promote the rational use of national essential medicines in clinic， and to provide reference for the further implementation of new National Essential Medicines List. METHODS： The application data of national essential medicines in our hospital from 2011 to 2013 were collected from hospital information system （HIS）. The drug name， amount and sum were analyzed statistically. RESULTS： From 2011 to 2013， the kinds of national essential medicines were 179， 183 and 187 in our hospital， accounted for 34.42％，35.19％ and 35.96％ of new National Essential Medicines List， respectively； the consumption sum of national essential medicines accounted for 19.49％， 17.56％ and 18.17％ of total in our hospital， respectively； the top 3 national essential medicines were regulating water， electrolyte and acid-base balance regulation drugs， anti-microbial drugs and anti-cancer drugs in the list of consumption sum； Sodium chloride injection and Glucose injection were the top 2 consumption sum of western medicines in national essential medicines； and Shenmai injection still held the top 1 in Chinese patent medicine. CONCLUSIONS：In recent years， the proportion of national essential medicines used in cardiovascular system in our hospital is low， and there is still a gap between the clinical actual demands. The varieties and consumption sum of national essential medicines for each category is relatively concentrated， the national essential medicines coverage rate and utilization rate remains to be further improved.