OBJECTIVE： To establish a pharmacy online to offline （O2O） platform service quality evaluation model， and to provide reference for platform operators to improve the service quality. METHODS： Using SERVQUAL scale， combining the situation of pharmacy O2O platform development in China， the reliability， safety and aspects of O2O platform were analyzed to sum up primary evaluation index of pharmacy O2O platform service quality. Based on this， the expert interviews questionnaire was designed. According to the questionnaire results， indicators were modified and empowered to construct the pharmacy O2O platform service quality evaluation model； the reliability and validity of model were validated. RESULTS & CONCLUSIONS： According to the connotations of each dimension analysis in the SERVQUAL scale and expert interview results of pharmacy O2O platform service quality， pharmacy O2O platform service quality evaluation model is constructed， including five indicators as “reliability” “security”， and 18 secondary indexes as the “number of platform pharmacy” “pharmacy qualification show” “pharmacy type”. The results of model index reliability and validity verification show that model construction is reasonable and can provide reference for platform operators improving service quality. Follow-up research should give full consideration to the Chinese consumer behavior habits， personal preferences and other factors to build more suitable pharmacy O2O platform service quality evaluation model in China.