OBJECTIVE：To investigate the satisfaction degree of outpatients on policy of separation of clinical pharmacy from 4 third grade hospitals in Shanghai， and provide reference for promoting medical reform policy. METHODS： Parts of outpatients in the 4 new suburb third grade hospitals were investigated by the questionnaire and interview in Shanghai city， and the data was statistically analyzed by Excel software and SPSS 19.0 software. RESULTS： Totally 400 questionnaires were sent out and 368 were valid with effective recovery of 94.3％. The awareness rate of medical separation policy was 81.3％ in the outpatients； 55.5％ of outpatients thought that medicine cost savings effect was not obvious； the overall satisfaction of patients was 91.6％， and the highest of satisfaction was the service attitude and the lowest was medical expenses. CONCLUSIONS：Policy of separation of clinical pharmacy has reduced the medical expenses， guided the triage treatment of patients partly and improved the satisfaction of patients. It is suggested to shorten the waiting time by optimizing examination process， strengthen price regulation in drug， standardize production and distribution process， improve use rate of essential medicines and promote clinical rational drug use for further improvement of satisfaction.