OBJECTIVE：To provide reference for rational use of polycystic ovary syndrome（PCOS）drugs. METHODS：The utilization of PCOS drugs in our hospital during Jan.-Dec. 2013 were analyzed in respects of consumption sum，DDDs，sorting and so on. The rationality of prescription was analyzed according to guidelines and drug package inserts and so on. RESULTS：There were 1 551 prescriptions，involving 76 kinds of drugs，and their total consumption sum was 181 072.90 yuan. Main types of drugs were hormone related drugs（accounting for 81.37％ of prescription frequency，73.51％ of consumption sum）and Chinese patent medicine （accounting for 15.41％ of prescription frequency，19.43％ of consumption sum）. Top 5 hormone drugs in the list of DDDs were Ethinylestradiol and Cyproterone acetate tablets，Metformin hydrochloride enteric-coated tablets，Progesterone soft capsule， Dydrogesterone tablets and Progesterone soft capsules. Top 5 Chinese patent medicines in the list of DDDs were Kuntai capsule， Yougui capsule，Huanshao capsule，Jiawei xiaoyao capsule and Nvjin capsule. Single drug accounted for 72.08％ in prescription. The proportion of irrational drug use was 1.69％. CONCLUSIONS：The application of drug in patients with PCOS is reasonable generally. Some prescriptions are unreasonable，mainly manifesting as incomplete clinical diagnosis，irrational usage and dosage. Pharmacists should strengthen prescription verification and intervention.