OBJECTIVE： To observe clinical efficacy and safety of Jiedu xiaoyu cream combined with Glucosamine potassium sulfate capsules in the treatment of knee osteoarthritis.  METHODS： 196 patients with knee osteoarthritis were randomly divided into observation group and control group， with 98 cases. Both group were given Glucosamine potassium sulfate capsules 0.5 mg/time， bid； observation group additionally received Jiedu xiaoyu cream for local use， once a week； control group additionally received Diclofenac diethylamine emulsifiable paste for local use， bid. A treatment course lasted for 2 weeks， and both groups received 3 courses of treatment.  Clinical efficacy， VAS scores， WOMAC scores and ADR of 2 groups were observed. RESULTS： The total effective rate of observation group was 94.7％， which was significantly higher than that of control group （88.3％）， with statistical significance （P＜0.05）. Compared with before treatment， VAS and WOMAC scores of 2 groups decreased obviously， with statistical significance （P＜0.05）； the decrease of observation group was more significant than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Jiedu xiaoyu cream combined with Glucosamine potassium sulfate capsules has good clinical efficacy in the treatment of knee osteoarthritis， can relieve knee pain and improve the function of activity.