OBJECTIVE： To evaluate the effects of different doses of flurbiprofen axetil on analgesia effects of patients after laparoscopic cholecystectomy. METHODS： 120 patients undergoing laparoscopic cholecystectomy were selected and randomly divided into group A， B and C， with 40 cases in each group. Group A， B and C were given the mixture 100 ml of flurbiprofen axetil 100， 150 and 200 mg combined with tramadol 600 mg and ondansetron 4 mg respectively and 0.9％ Sodium chloride injection for patient controlled intravenous analgesia （PCIA） at the end of operation. Mean arterial pressure （MAP）， heart rate （HR） and static and dynamic visual analogue scale （VAS） scores were observed in 3 groups at the end of operation， 4， 8， 24 and 36 h after surgery. The incidence of incision pain， neck-shoulder pain and hypochondrium， the occurrence of ADR were recorded 36 h after operation. RESULTS： After operation，There was no statistical significance in comparison of 3 groups with MAP，HR， static and dynamic VAS （P＞0.05），4， 8， 24， and 36 h after operation， MAP， HR， static and dynamic VAS score of group B and C decreased significantly， there was statistical significance， compared with group A （P＜0.05）； there was no statistical significance in above indicators between group B and group C （P＞0.05）. After operation， the incidence of incision pain， neck-shoulder pain and hypochondrium in group A were significantly higher than group B and C， with statistical significance （P＜0.05）， but there was no statistical significance  between group B and group C （P＞0.05）. After operation， the incidence of ADR in group A and B were significantly lower than in group C， with statistical significance （P＜0.05）， but there was no statistical significance between group A and group B （P＞0.05）. CONCLUSIONS： Flurbiprofen axetil 150 mg combined with tramadol 600 mg and ondansetron 4 mg can improve hemodynamics and patient controlled intravenous analgesia in patients underwent laparoscopic cholecystectomy with lower incidence of ADR.