OBJECTIVE： To screen and optimize processing parameters of extraction， concentration， drying and granulation of Lysimachia christinae dispensing granules. METHODS： Taking extracting rate of quercetin and kaempferide， yield of solid extracts as indexes， orthogonal test was employed for optimize the extraction parameters. The temperature of vacuum concentration was screened by the stability of quercetin and kaempferide. The parameters of spry drying technology was screened by orthogonal test taking moisture content， the amount of quercetin and kaempferide， extract powder yield as evaluation indicator. The parameters of dry granulation were screened by granules yield and granules property. The optimized parameters were validated. RESULTS： The optimal preparation technology of L. christinae dispensing granules was as follows as adding 14， 12 and 12 folds water， extracting for 3 times， lasting for 0.5 h each time； vacuum concentration temperature 80 ℃ and relative concentration density 1.08； powdered extract prepared by spray drying method （inlet air temperature of spry drying 120 ℃ and atomization pressure 45 MPa）， and mixed with 0.5％ magnesium stearate to prepare granules by dry granulation （screw speed 40 r/min， roller speed 8      r/min， roller press 16 kg/cm2）. In validation test， RSDs of each indicator were all no more than 5.48％ （n＝3）， and average total content of quercetin and kaempferide was 2.43 mg/g. CONCLUSIONS： Optimized technology is stable and feasible， and it can provide guidance for scale-up and large-scale production of L. christinae dispensing granules.