OBJECTIVE： To investigate the characteristics of ADR induced by psychotropic drugs in children and adolescent of our center， and to provide reference for clinical drug use. METHODS： ADR induced by psychotropic drugs in children and adolescent reported by our center from 2005 to 2015 were investigated and analyzed retrospectively. RESULTS： A total of 177 ADR were collected， of which the most cases were induced by antipsychotic drugs as risperidonal， olanzapine and quetiepine. The most common ADR were central and peripheral nervous system disorders （117 cases， 37.86％）， followed by endocrine disorder （35 cases，11.32％）， heart rate and rhythm disorders （32 cases， 10.35％） and liver and biliary system disorders （17 cases， 5.50％）. By the relative titer of haloperidol， most of ADR were induced by haloperidol with dose of 4 mg， 6 mg and 8 mg once a day （34， 29 and 53 cases）. Most of cases occurred within a week （94 cases， 53.11％）. CONCLUSIONS： To develop and strengthen clinical application and ADR monitoring of psychotropic drugs in children and adolescents should be regarded as the key to ensure drug use safety.