OBJECTIVE： To optimize water extraction and alcohol precipitation technology of Tongfengxiao granules. METHODS： The effects of the amount of water， extraction time and extraction times on water extraction technology were investigated by orthogonal test using the content of berberine hydrochloride and salvianolic acid B as index. The effects of the relative density of liquid， alcohol content and processing time on alcohol precipitation technology were investigated by orthogonal test using the retention rate of berberine hydrochloride and salvianolic acid B as index. Validation test was conducted. RESULTS： The optimal water extraction technology was as follows as 8-fold water， decocting for 3 time， lasting for 60 min each time. The optimal alcohol precipitation technology was as follows as relative density of extraction liquid concentrated to 1.15， the content of alcohol 80％ after adding alcohol following cooling， placing for 48 h， removing precipitation. Results of validation test indicated the average contents of berberine and salvianolic acid B were 6.344 6 （RSD＝2.46％， n＝3） and 7.312 2 mg/g （RSD＝1.08％， n＝3）， and retention rate of them were 91.03％ （RSD＝1.72％， n＝3） and 92.39％ （RSD＝1.50％， n＝3）. CONCLUSIONS： The optimized water extraction and alcohol precipitation technology are feasible and producible， and suitable for the extraction， separation and purification of the preparation.