OBJECTIVE： To evaluate the effect of for antibiotics special rectification. METHODS： The antibiotics special rectification of our hospital was conducted through plan-do-check-action of PDCA cycle， and the effects of special rectification was analyzed in 4 years before and after the PDCA cycle management. RESULTS： After 4 PDCA cycle， the types of antibacterials was adjusted to 49 after rectification from not limited before rectification. The antibiotics cost per capita decreased from 961.83 yuan to 381.94 yuan， and the percentage of antibiotics cost in total cost decreased from 17.76％ to 8.30％. The antibacterial index were all up to the requirements of Health and Family Planning Commission after rectification； the detection rate of microorganism in the inpatients receiving antibacterials for limit or special use increased from 17.61％ and 51.61％ to 81.40％ and 95.24％. The proportion of antibacterial for clean surgery decreased from 71.83％ to 18.79％. After rectification， the reasonable rate of antibacterial selection， medication timing， medication course all reached 95％ above. CONCLUSIONS： The effect of PDCA cycle shows obvious effect on continuous improvement of antibacterials in hospital， and it can be brought into the normal management of antibacterials in hospital.