OBJECTIVE： To explore the effect of nifedipine combined with losartan on the blood pressure and renal function of hypertension complicated with coronary heart disease. METHODS： 150 patients with hypertension complicated with coronary heart disease were randomly divided into observation group and control group. Control group was orally treated with Nifedipine sustained release tablet 30 mg， once a day； observation group was additionally treated with Losartan potassium capsules 50 mg， once a day. The treatment course for both groups was 1 month. Systolic blood pressure， diastolic blood pressure， renal function indicators before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： After treatment， systolic blood pressure and diastolic blood pressure after 3 months was lower than 1 month and lower than before treatment in same group， renal function indicators were significantly lower than before treatment， and observation group was lower than control group， the differences were statistically significant（P＜0.05）； the incidence of adverse reactions in observation group was significantly lower than control group， the difference was statistically significant （P＜0.05）. CONCLUSIONS： Nifedipine combined with losartan can well control the blood pressure of hypertension complicated with coronary heart disease， protect renal functions， with good safety.