OBJECTIVE：To compare therapeutic efficacy and safety of laparoscopy combined with dienogest and laparoscopy combined with dienogest and TCM in the treatment of endometriosis. METHODS：126 endometriosis patients were selected and divided into control group and observation group，with 63 cases in each group. Control group received combined with dienogest（25 mg/ time，qd）；observation group was additionally given TCM on the basis of control group. Therapeutic efficacy，recovery time of ovulation， menstrual recovery time and ADR were compared between 2 groups，and recurrence and pregnancy of them were followed up for 2 years. RESULTS：The total effective rate of observation group（93.65％）was significantly higher than that of control group （80.96％），with statistical significance（P＜0.05）. The menstrual recovery time and recovery time of ovulation in observation group were significantly shorter than control group，with statistical significance （P＜0.05）. The incidence of ADR in observation group （9.52％）was significantly lower than control group（26.98％），with statistical significance（P＜0.05）；the recurrence rate of observation group（4.76％）was significantly lower than that of control group（17.46％），with statistical significance（P＜0.05）. In 2-year follow-up，there were 23 pregnancy patients in observation group，which was significantly higher than that of control group（9 cases）， with statistical significance（P＜0.05）. CONCLUSIONS：Laparoscopy combined with dienogest and TCM in the treatment of endometriosis have better clinical effect，higher safety and lower recurrence rate. The patients are easily pregnant.