OBJECTIVE：To explore hospital pharmacists service mode and the subject construction of hospital pharmacy. METHODS： Through reviewing the transformation process of hospital pharmacy and pharmacist’s duty，the present structure，content， working model and achievements of pharmacy in our hospital were introduced based on“large pharmacy”of taking clinical pharmacy as core，paying attention to personnel training，technical innovation，physican，pharmacist and nurse cooperation，multiple discipline integration，etc.；the direction of hospital pharmacy was explored. RESULTS：Many adjustments were made to facilitate the smooth and orderly development of hospital pharmacy under the new situation，as that establish the rational drug use and quality safety system，drug supply and operation management system working mode；that the development strategy of pharmacy was identified as“focusing on the rational drug use，combining the management function”and“providing professional pharmaceutical care for the clinic and patients，providing professional technical support for the hospital decision and medical management”； that the construction of clinical pharmacy specialty/key discipline and drug clinical trial technology platform in accordance with the international standard and so on were lined in the project of pharmacy；that quality control circle was cited，pharmaceutical supervision and pharmaceutical care were expanded to the public and the fine；that a fine，professional pharmacist team was cultured. CONCLUSIONS：The construction of future hospital pharmacy needs the concept of“large pharmacy”with multi-disciplinary integration to develop towards standardization，refinement，specialization and modernization.