OBJECTIVE： To discuss the effects of Kangshuling gel on wound treatment and infection prevention inⅡdegree burns. METHODS： 60 patients with Ⅱ degree burns were randomized intro observation group and control group， with 30 cases in each group. Based on routine treatment （cleaning， disinfection， necrotic tissue removal， antibiotics use）， observation group was given Kangshuling gel， and control group was treated with sulfadiazine. The average healing rate， healing time， surgical dressing exudate， inflammatory reaction around wound， the times of dressing change and inner layer gauze change， and wound infection rate were observed in 2 groups， and satisfaction survey was conducted in 2 groups. RESULTS： On 14th and 18th day after treatment， average rate of wound healing in observation group was significantly higher than in control group； the time of wound healing was significantly shorter than control group， with statistical significance （P＜0.05）. Within 2 weeks after treatment， the number of gauze layer wetted by surgical dressing in observation group was significantly less than in control group， and case number of inflammatory reaction around wound was significantly less than control， with statistical significance （P＜0.05）. The times of dressing change and inner layer gauze change in observation group was significantly less than in control group， and the rate of wound infection was significantly less than control group， with statistical significance （P＜0.05）； the satisfaction of observation group was better than that of control group， with statistical significance （P＜0.05）. CONCLUSIONS： Kangshuling gel in the treatment of Ⅱ degree burns can effectively prevent and treat wound infection， reduce the rate of wound infection and the times of dressing change， shorten the time of wound healing and improve the rate of wound healing so， high satisfaction degree is obtained.