OBJECTIVE： To prepare Breviscapine solid dispersion sustained-release tablet and investigate its drug release property. METHODS： The solid dispersion was prepared by hot melt extrusion method. Using dissolution rate as index， single factor test was used to optimize drug-loading material and drug-loading ratio. The status of breviscapine in solid dispersion were investigated by SEM. Breviscapine sustained-release tablet was prepared by total powder tabletting using HPMC K15M as framework material， lactose as filler， magnesium stearate as lubricant， gum arabic as flow aid. Drug release property in vitro of Breviscapine sustained- release tablet was compared with commercial Breviscapine tablet. The dynamic character of drug release process was fitted. RESULTS： The optimal carrier was PVP VA64， and optimal drug-loading ratio was 1 ∶ 5； accumulative dissolution rate of prepared solid dispersion was 99.61％ within 1 h； breviscapine crystal form hadn’t been found in solid dispersion. Accumulative dissolution rate of commercial tablet reached 98％ above within 1 h， while that of prepared tablet was about 98％ within 12 h. Drug release behavior of prepared tablet fitted to zero-order drug release dynamic characters. CONCLUSIONS： Breviscapine sustained-release tablet is prepared successfully， and the preparation technology is simple and practical.