OBJECTIVE： To observe therapeutic efficacy and toxic reaction of arterial interventional chemotherapy for cervical cancer patients after laparoscope surgery. METHODS： 160 patients with cervical cancer were randomly divided into treatment group and control group， with 80 cases in each group. Both groups received laparoscope assistied vagina hysterectomy. After surgery， control group was given traditional intravenous chemotherapy of paclitaxel+carboplatin （TC scheme）； treatment group was given TC scheme arterial interventional chemotherapy. Effective rate， survival time， survival rate and toxic reaction were observed in 2 groups after treatment. RESULTS： After treatment， effective rate of treatment group （90.0％） was significantly higher than that of control group （75.0％）， with statistical significance （P＜0.05）. Mean survival time of treatment group and control group was （23.45±5.33） month and （19.29±6.13） month， and survival rates of 2 groups were 91.3％ and 78.8％， with statistical significance （P＜0.05）. Both groups suffered from gastrointestinal reactions as myelosuppression， nausea， vomiting at different degree； the case number and severity of toxic reaction in treatment group were significantly lower than control group， with statistical significance （P＜0.05）.  CONCLUSIONS： Arterial interventional chemotherapy can improve chemotherapy effect of malignant cervical cancer with less toxic reaction， and promote survival of patients.