OBJECTIVE：To establish the quality standard for Cangbai qutong capsule. METHODS：TLC was conducted to identify the Rhizoma atractylodis，Asarum sieboldii，Paeoniae Radix Rubra and Cortex phellodendri；RP-HPLC was conducted to determine the content of berberine hydrochloride. The column was Waters Symmetry-C18 with mobile phase of acetonitrile-0.1％ phosphoric acid（gradient elution）at flow rate of 1.0 ml/min，the detection wavelength was 265 nm，column temperature was 30 ℃， and the injection volume was 10 μl. RESULTS：TLC showed R. atractylodis，A. sieboldii，Paeoniae Radix Rubra and C. phellodendri had clear spots and good separation. The linear range of berberine hydrochloride was 21.12-84.48 μg/ml（r＝0.999 6）；RSDs of precision， stability and reproducibility tests were lower than 3％；recovery was 96.439％-100.950％（RSD＝1.34％，n＝9）. CONCLUSIONS： The method is simple and reproducible，and can be used for the quality standards of Cangbai qutong capsule.