OBJECTIVE：To explore the role and breakthrough point of clinical pharmacist in the anti-infective therapy for a patient with purulent meningitis. METHODS：Clinical pharmacists provided pharmaceutical care for a patient with purulent meningitis， assisted physicians to adjust therapy plan of antibiotics，i.e. anti-infective therapy of vancomycin+ceftriaxone sodium，meropenem+ vancomycin，levofloxacin+vancomycin successively；disposed ADR induced by meropenem and levofloxacin. RESULTS：The physicians adopted the suggestions of clinical pharmacists，the infection symptom had been controlled，and ADR disappeared；and then the patient was discharged from hospital. CONCLUSIONS：Clinical pharmacists provide pharmaceutical care for patient with purulent meningitis，assist the physicians to develop safe and effective anti-infective therapy plan，and dispose ADR timely so as to promote rational drug use in the clinic.