OBJECTIVE：To provide reference for cultivating high-level comprehensive medical talents with high quality. METHODS：Based on the market and social needs，the teaching reform was conducted from the concepts of educational ideas， modes，curriculum system，contents，management and other aspects. RESULTS：In order to adapt to the needs of society and era， it should establish large education educational ideas to cultivate student’s independent ability to obtain knowledge and self-development to make people change into community basic services and service and dedicate society with modes of cultivating inter-disciplinary talents，including combination of prduction and study，foundation strengthening，professional expanding，penetration of science and technology and combination of arts and science；generally optimize curriculum system with the“principle of precise definition， clear classification，and optimized combination based on market and social needs”；and update contents timely and teaching materials；the teaching management should be changed from closed off management of the past to the external management which dominated by the market assessment. CONCLUSIONS：Reform of medical higher education based on the market and social needs can cultivate the talents with high quality and comprehensive medical knowledge for the social needs，which is conductive to the development of medical industry.