OBJECTIVE：To promote the working efficiency of hospital prescription evaluation and improve pharmacists professional quality through developmenting electronic prescription evaluation system（EPES）for outpatient department used by taking full advantage of large amount of information of electronic prescription. METHODS：By using system structure of Client/Server， Web Service middleware，programming tool of PowerBuilder and database technique of Oracle and sharing Hospital information system data，EPES was designed and applied，which could collect prescription information and generate summary form automatically after artificial prescription evaluation. RESULTS & CONCLUSIONS：Integration of outpatient electronic medical records，historical prescriptions and medical test results query system make the EPES carry comprehensive information which could make up for disadvantages of paper prescription form in the aspect of obtaining outpatient medical records，historical prescriptions or medical test results. EPES can accomplish general and special prescription evaluation and also pledges the equity and justness of process by random sampling. The operation of the system could improve the efficiency from taking 24-36 h in paper prescription form to 4-6 h to complete general prescription evaluation，which also improves professional quality of pharmacists by intensive training.