OBJECTIVE：To systematically review the efficacy and safety of Deproteinised calf blood serum injection in the treatment of cerebral infarction， and to provide evidence-based reference for clinical treatment.METHODS：Retrieved from Cochrane Library， EMBase， Medline， CBM， CJFD， VIP and Wanfan database， randomized controlled trials （RCT） about theefficacy and safety ofDeproteinised calf blood serum injection （test group） based on basic treatment （control group） in the treatment of cerebral infarction were collected.Meta-analysis was performed by using Rev Man 5.2 software after data extraction and quality evaluation with Cochrane system evaluation manual 5.1.0.RESULTS： A total of 18 RCTs were included， involving 2 111 patients.Results of Meta-analysis showed the total effective rate [OR＝3.30，95％CI（2.48，4.39），P＜0.001]， National Institutes of Health Stroke Scale （NIHSS） score[MD＝－1.47，95％CI（－2.06，－0.88），P＜0.001] and activities of daily living（ADL） score[MD＝9.09，95％CI（6.46，11.72），P＜0.001] in test group were significantly better than control group，there were significant differences between the 2 groups； and there was no obvious adverse reactions during treatment. CONCLUSIONS： Both efficacy and safety of Deproteinised calf blood serum injectionin the treatment of cerebral infarction are good.