OBJECTIVE： To explore the process of clinical pharmacists participating in the voriconazole anti-fungal therapy for patients with liver failure. METHODS： Clinical pharmacists participated in the voriconazole therapy for patients with invasive Aspergillus disease complicated with liver failure， monitored blood concentration regularly， check the reasons for ADR， assisted physicians to adjust voriconazole therapy plan and evaluate therapeutic efficacy. RESULTS： Physicians adopted the suggestion of clinical pharmacists， and patient’s ADR disappeared to avoid cumulative intoxication of voriconazole and promote infection recovery. CONCLUSIONS： Clinical pharmacists participate in treatment and carry out blood concentration monitoring to guide drug therapy and guarantee the safety and effectiveness of drug use.