OBJECTIVE：To investigate the clinical application of warfarin in inpatients of our hospital，and provide reference for standardized application in clinic. METHODS：Totally 267 inpatients records used warfarin in our hospital from Jan. 2013 to Jun. 2014 were investigated to retrospectively analyze the indications，dosage，international normalized ratio（INR）monitoring and bleeding complications of warfarin. RESULTS：Warfarin was mainly used for patients with deep vein thrombosis，cerebral infarction， rheumatic heart disease and pulmonary embolism in our hospital；the dosage of inpatients was in the range of 0.625-6.875 mg with average daily dosage of（2.15 ± 0.72）mg；the INR lower than 1.8 accounted for 52.8％ ，the INR in the range of 1.8-3.0 （reaching the standard）accounted for 31.8％ and INR higher than 3.0 accounted for 15.4％；incidence of adverse reactions was 5.6％ ，mainly subcutaneous blood spots （petechiae） and urine occult blood，and incidence of severe hemorrhage （intracerebral hemorrhage）was 0.7％. CONCLUSIONS：At present，the clinical application of warfarin is still deficient，and qualified rate of INR is still low. It’s important to actively carry out medication intervention and clinical pharmaceutical care.