OBJECTIVE： To compare pharmacoeconomic and effect of Xueshuantong for injection and Ginkgo leaf extract and dipyridamole injection in the treatment of ischemic stroke. METHODS： Retrospective study was conducted. Totally 404 inpatients with ischemic stroke were divided into Xueshuantong group （271 cases） and ginkgo leaf extract and dipyridamole group （133 cases） according to clinical treatment programs. Based on the conventional treatment， patients in 2 groups were given Xueshuantong for injection and ginkgo leaf extract and dipyridamole injection， respectively. The average treatment course was 10 d. Cost-minimization analysis was performed with the determination index of total effective rate. RESULTS： The total effective rates in Xueshuantong group and ginkgo leaf extract and dipyridamole group were 90.77％ and 88.72％， respectively， the difference was not statistically significant（P＞0.05）. The costs in 2 groups were 12 860.21 yuan and 13 155.40 yuan， respectively， and xueshuantong group had lower than ginkgo leaf extract and dipyridamde group. CONCLUSIONS： Both  Xueshuantong for injection and Ginkgo leaf extract and dipyridamole injection are effective in the treatment of ischemic stroke. However， the economy of Xueshuantong for injection is superior to the other one.