OBJECTIVE： To observe the efficacy and safety of moxifloxacin combined with Jiehe pill in the treatment of muilt drug-resistant tuberculosis （MDR-TB）. METHODS： 116 patients with MDR-TB were randomly divided into control group and observation group. Control group was given Moxifloxacin hyohochloride tablet 0.4 g once a day，observation group was additionally given Jiehe pill 9 g， twice a day，and 2 groups were given rifapentine， albendazole isoniazid， amikacin， pasiniazide， pyrazinamide， p-amino salicylic acid and other conventional treatment. The treatment course for both groups was 18 months. The clinical efficacy， and T cell subsets （CD3+，CD4+，CD4+/CD8+），interferon（INF）γ，interleukin（IL）4 levels before and after 6， 12 and 18 months， and incidence of adverse reactions in 2 groups were recorded. RESULTS：The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）. After treatment， CD3+，CD4+，CD4/CD8 and INF-γ level in 2 groups were significantly higher than before and gradually increased by time， and observation group was higher than control group； IL-4 level was significantly lower than before and graually decreased by time， and observation group was lower than control group， the differences were statistically significant（P＜0.05）. There was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS：Based on the coventional treatment， moxifloxacin combined with Jiehe pill has better efficacy than moxifloxacin in the treatment of MDR-TB，with similar safety.