OBJECTIVE： Taking metoprolol succinate sustained-release tablets as an example， to explore the value of speckle tracking imaging in therapeutic efficacy evaluation of CHF drugs. METHODS： 68 CHF patients who had never underwent regular treatment were given Metoprolol succinate sustained-release tablets and anti-heart failure agents for 3 months. NYHA classification， resting heart rate （RHR）， 6 min walk distance （6MWD） and conventional echocardiographic measurements were tested before and 1 and 3 months after treatment. Dynamic image were collected in the apical 2-chamber view， apical 4-chamber view and left ventricular long axis plane for speckle tracking imaging offline analysis. The left ventricular global longitudinal strain （LVGLS） were measured. After 3 months of treatment， CHF patients were divided into standard group （group A， RHR 55-60 times/min） and nonstandard group （group B， RHR＞60 times/min） according to resting heart rate. The improvement of above indicators were compared between 2 groups， and that of LVGLS was also compared. RESULTS： After 1 month of treatment， RHR， LVEDd， LVEF and LVGLS of group A were improved significantly， compared with group B， with statistical significance （P＜0.05）. After 3 months of treatment， there was statistical significance in above indicators between 2 groups （P＜0.05）. In group A， RHR， 6MWD and LVGLS improved significantly after 1 month of treatment， there was statistical significance， compared with before treatment （P＜0.05）； there was statistical significance in above indicators after 3 months of treatment， compared with before treatment and after 1 month of treatment （P＜0.05）. In group B， RHR and 6MWD improved significantly after one month of treatment； there was statistical significance， compared with before treatment （P＜0.05）； there was statistical significance in significant improvement of each indicator between after 3 months of treatment and before treatment （P＜0.05）； only there were statistical significance in RHR and NYHA grading， compared with after one month of treatment （P＜0.05）. CONCLUSIONS： Speckle tracking imaging can early reflect the left ventricular function improvement of CHF patients after anti-heart failure treatment， especially in patients with RHR control standard earlier and more significant. Speckle tracking had good clinical application value in the follow-up treatment of heart failure as routine evaluation index.