OBJECTIVE： To optimize the extraction technology of Compound shuangjin ganmao granules. METHODS： The effects of ethanol volume fraction， extraction time and the amount of ethanol on the extraction effect of ethanol were investigated by orthogonal test using the content of effective components of orientoside， vitexin and rupestonic acid in Trollius chinensis and Artemisia rupetris， and the yield of extract as indexes. The effects of decoction times， decoction time and the amount of added water on the extraction effects were investigated using the contents of effective components of total polysaccharide and rosmarinci acid in Hyssopus officinalis， and the yield of extraction as indexes. Validation test was conducted. RESULTS： Optimum ethanol extraction technology conditions were as follows as 10-fold 70％ ethanol， extracting for 2 times， lasting for 1.5 h each time. Optimum water extraction technology conditions were as follows as 10-fold water， extracting for 3 times， lasting for 1 h each time. Results of validation test showed that average comprehensive score of ethanol extraction technology and water extraction technology were 95.55 （RSD＝1.01％， n＝3） and 97.89 （RSD＝0.97％， n＝3）. CONCLUSIONS： Optimized extraction technology is simple， stable and feasible， which can be used for the extraction of Compound shuangjin ganmao granules.