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ZHU Dongchun; FANG Ling; LIU Jiatao; SUN Xuqun; XU Dujuan; QIAN Yong; ZHANG Congjun

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更新时间：2023-03-01

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- China Pharmacy Vol. 27, Issue 5, (2016)
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ZHU Dongchun, FANG Ling, LIU Jiatao, et al. [J]. China Pharmacy 27(5).(2016)
DOI：

ZHU Dongchun, FANG Ling, LIU Jiatao, et al. [J]. China Pharmacy 27(5).(2016) DOI：

摘要

目的：探讨临床药师在对奥沙利铂致过敏反应进行药学监护中的作用。方法：临床药师参与1例奥沙利铂致过敏反应患者的药学监护，在患者出现过敏反应时建议停用奥沙利铂，给予地塞米松注射液5 mg，之后减缓奥沙利铂滴注速度。结果：医师采纳临床药师建议，给予地塞米松注射液5 min后，患者过敏反应减轻；在严密监测下继续治疗，患者未再出现类似过敏反应。结论：奥沙利铂为常用抗肿瘤药物，医务人员应熟悉其不良反应的预防、诊断与治疗，对含奥沙利铂的化疗方案提前进行评估，筛查患者过敏的高危因素。临床药师参与药物治疗的药学监护，有利于药品不良反应监测，可促进临床更加安全、合理用药。

Abstract

OBJECTIVE： To explore the role of clinical pharmacists on pharmaceutical care for allergic reaction caused by oxaliplatin. METHODS： Clinical pharmacists conducted pharmaceutical care for a patient with oxaliplatin-induced allergic reaction， and suggested stopping taking oxaliplatin， giving Dexamethasone injection 5 mg and then slowing down injection speed. RESULTS： Physicians adopted the suggestions of clinical pharmacists. Allergic reaction relieved 5 min after giving Dexamethasone injection. The patient didn’t suffered from this allergic reaction again under tight supervision. CONCLUSIONS： Oxaliplatin is often used for tumor therapy. Medical staff should be familiar with the prevention， diagnosis and treatment of ADR， evaluate oxaliplatin chemotherapy plan in advance and screen high risk allergy factor. The participation of clinical pharmacists in pharmaceutical care contribute to ADR monitoring and promote safe and rational drug use in the clinic.

关键词

奥沙利铂药品不良反应抗肿瘤药物药学监护临床药师

Keywords

OxaliplatinADRAnti-tumor drugPharmaceutical careClinical pharmacist

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Dept. of Pharmacy， Second Affiliated Hospital， Army Medical University

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