OBJECTIVE：To exlpore the effect of telmisartan combine with benazepril on plasma brain natriuretic peptide （BNP） of patients underwent permanent cardiac pacemaker implantation. METHODS：96 patients underwent permanent cardiac pacemaker implantation were randomly divided into group A，B and C with 32 cases in each group. Based on routine treatment， group A was given telmisartan 80 mg/d immediately after operation，qd，group B given benazepril 10 mg/d，qd，group C given telmisartan 40 mg/d+ benazepril 10 mg/d，qd. All of them was given medicine for 6 months. LEVF，CI，Ren，BNP，AngⅡ and Ald were compared among 3 groups. RESULTS：After 6 months，BNP levels of 3 groups were higher than before，with statistical significance（P＜0.05）. LVEF and CI of group C had no statistical significance before and after treatment（P＞0.05）；those of group A and B were decreased，with statistical significance（P＜0.05）；those of group C were higher than those of group A and B， with statistical significance（P＜0.05）. The levels of Ren，AngⅡ and Ald in 3 groups were decreased after treatment，with statistical significance（P＜0.05）；those of group C were lower than those of group A and B，with statistical significance（P＜0.05）. CONCLUSIONS：Telmisartan combined with benazepril can improve ventricular remodeling and heart function，and reduce plasma BNP levels in patients underwent permanent cardiac pacemaker implantation.