OBJECTIVE： To investigate the characteristics and clinical manifestations of adverse drug reaction（ADR） related to moxifloxacin on elderly patients， and provide references for clinical drug. METHODS： Moxifloxacin-induced ADR reports of elderly patients collected by Beijing ADR Monitoring Center in 2012 were analyzed statistically. RESULTS： Among 293 ADR cases， there were a majority of male patients （55.63％）， mainly aged 70-79 years old （35.84％）； main clinical manifestations were lesion of skin and its appendants （30.07％）， nervous system reaction （27.68％）， circulatory system damage （13.37％） and gastrointestinal system reaction （10.74％）， especially rash， pruritus， palpitation， nausea， psychogeny， phlebitis. Most ADRs occurred within 24 h （56.31％）. The incidence of ADR induced by intravenous administration was significantly higher than that of oral administration （92.15％ vs. 7.85％）. There were 16 cases of severe ADR.  CONCLUSIONS： Great importance should be attached to the ADR induced by moxifloxacin in the elderly and the occurrence of serious ADR.