OBJECTIVE： To discuss effects of Bifid triple viable capsules combined with Dahuang chishao decoction on endotoxemia and intestinal mucosal barrier function of patients with hepatocirrhosis. METHODS： 90 patients with hepatocirrhosis were randomly divided into traditional Chinese and western medicine group and western medicine group with 45 cases in each group. Both groups were given symptomatic treatment， such as liver protection and diuresis， lowering portal pressure and nutrition support. Based on this， western medicine group was given Bifid triple viable capsules 0.42 g， tid， po； traditional Chinese and western medicine group was additionally given Dahuang chishao decoction orally， one dose a day， on the basis of western medicine group. Both 2 groups were treated for 6 weeks. The changes of liver function index， serum endotoxin （ET）， procalcitonin （PCT） and diamine oxidase （DAO） levels of patients were observed and recorded in 2 groups before and after treatment. RESULTS： After 6 weeks treatment， serum ALT， AST and TBIL， ET， PCT and DAO levels of patients in 2 groups declined significantly， compared with before treatment， with statistical significance （P＜0.05 or P＜0.01）； the decrease of traditional Chinese and western medicine group was more significant than western medicine group， with statistical significance （P＜0.05）. CONCLUSIONS： Bifid triple viable capsules combined with Dahuang chishao decoction can reduce ALT， AST and TBIL levels in patients with hepatocirrhosis， protect liver function； reduce serum ET， PCT and DAO levels， release endotoxemia， and protect and remedy intestinal mucosal barrier function.