OBJECTIVE：To investigate the effects of Ossotide tabletcombined with Xianling gubao capsule on the postoperative recovery effect oftrans-traumatic-verterbrae screw-setting combined with bone grafting in the treatment of osteoporotic thoracolumbar vertebral fractures. METHODS： 122 patients with osteoporotic thoracolumbar vertebral fractures who were treated with trans-traumatic-verterbrae screw-setting combined with bone grafting were randomly divided into control group and observation group.The two groups were treated by trans-traumatic-verterbrae screw-setting with bone grafting.Based on this， the control group was treated with 0.3-0.6 g Ossotide tablet， three times a day， taken orally after meals； observation group was additionally treated with 1.5 g Xianling gubao capsule， twice a day， taken orally after meals. Both of the two groups took medicine on the day of operation. A course induded 4 weeks，and it lasted 4 courses. The indexes were observed after 3 and 6 months treatment. The changes of pain score， bone mineral density （BMD） levels， bone gla protein （BGP）， bone alkali phsphatase （BALP）， procollagen I nterminal peptide （PINP） and other bone metabolism biochemical indexes in 2 groups before and after treatment were observed.Meanwhile，the clinical efficacy， rates of thoracolumbar vertebral refractures and incidence of adverse reactions in the 2 groups were recorded.RESULTS：After treatment， the total effective rate in observation group was significantly higher than control group， pain scores in 2 groups were significantly lower than before， and general decreased by time， observation group was lower than control group； BMD， BGP， BALP and PINP levels in 2 groups were significantly higher than before， and general increased by time， observation group was higher than control group； after 6 months， BMD， BALP and PINP levels in control group were significantly higher than before， the differences were statistically significant（P＜0.05）； there were no significant differences in the incidence of adverse reactions， rates of thoracolumbar vertebral refractures between 2 groups（P＞0.05）. CONCLUSIONS： Ossotide tablet combined with Xianling gubao capsule can significantly improve the bone metabolism biochemical indexes of patients， promote bone mineral density and fracture healing， with good safety in short-term medication.