OBJECTIVE：To reduce the risk of single dispensing，and to improve the quality of pharmaceutical care in emergency pharmacy. METHODS：Single dispensing environmental factors，human factors and social factors of emergency pharmacy in our hospital were analyzed；the suggestions and measures were put forward，risk intervention mechanism was established and management effects were evaluated. RESULTS：Through improving the pharmacy hardware and software，carrying out the relevant system， enhancing training，improving the process of dispensing and window order，promoting the drug management and carrying out near error management. Compared with before management（Oct.-Dec. 2014），the times of near error and disputes significantly reduced after management（Feb.-Apr. 2015）（P＜0.05），and medication error reduced to zero. CONCLUSIONS：As single dispensing， risk management and the improvement of prescription audit ability can improve pharmaceutical care in emergency pharmacy.