OBJECTIVE：To explore the effects of dehydroepiandrosterone（DHEA）combined with Meloxicam tablets on therapeutic efficacy of osteoarthritis and biochemical indicator. METHODS：104 patients with osteoarthritis were randomly divided into experimental group and control group with 52 cases in each group. Control group only received Meloxicam tablets，7.5 mg/time，bid；experimental group was additionally given DHEA，25 mg/time，qd，on the basis of control group. The treatment course of 2 groups was four weeks. The clinical efficacy，VAS score before and after treatment，joint function score，levels of IL-1 β and TNF-α，cartilage thickness，synovial thickness and score of liquid aggregation of joint cavity were compared between 2 groups. RESULTS：The total effective rate of experimental group（86.54％）was significantly higher than that of control group（69.23％），with statistical significance （P＜0.05）；compared with before treatment，VAS scores of 2 groups decreased significantly after treatment，while joint function scores increased significantly，with statistical significance（P＜0.05）. VAS score of experimental group was significantly lower than that of control group，while joint function score was significantly higher than control group，with statistical significance（P＜0.05）. After treatment，the serum levels of IL-1β and TNF-α in 2 groups significantly decreased，with statistical significance（P＜0.05）；those of experimental group were significantly lower than those of control group，with statistical significance（P＜0.05）；there was no statistical significance in the cartilage thickness between 2 groups before and after treatment（P＞0.05）. Compared with before treatment， the thickness of the synovial membrane and the score of liquid aggregation of joint cavity significantly decreased after treatment，with statistical significance（P＜0.05）；the thickness of synovial membrane and the score of liquid aggregation of joint cavity in experimental group were significantly lower than in control group，with statistical significance（P＜0.05）. CONCLUSIONS：DHEA combined with Meloxicam tablets is significant in the treatment of osteoarthritis，can significantly relief the pain and decrease the levels of serum IL-1β and TNF-α.