OBJECTIVE：To explore regularity and characteristics of ADR in our hospital，and to provide reference for rational drug use in the clinic. METHODS：A total of 368 ADR collected from Zhengzhou People’s Hospital during 2013-2014 were analyzed statistically in respects of patient’s gender，age，drug types，route of administration，dosage form，organs or systems involved in ADR，clinical manifestations，ADR outcome，etc. RESULTS：Of 368 ADR reports，female was more than male （52.99％ vs. 47.01％）；the number of patients aged more than 50 years was the most（36.14％）；most of ADR cases were induced by antibiotics and TCM preparations，accounting for 40.22％，21.47％，respectively；among route of administration，most of ADR cases were induced by intravenous administration（85.60％）；main clinical manifestations were lesion of skin and its appendants （39.95％），followed by digestive system （21.47％）. After treatment，all patients were cured or improved，no death case was found. CONCLUSIONS：Clinic should strengthen ADR monitoring and analysis and evaluarion，strengthen the rational use of antibiotics and TCM injections and adopt measures to reduce drug risk.