OBJECTIVE：To observe the clinical efficacy and safety of Yinzhihuang oral liquid in the adjuvant treatment of neonatal breast-feeding faundice. METHODS： 112 newborns with faundice were randomly divided into control group and observation group. Control group stopped breast-feeding for 3 d and given artificial feeding， as well as keeping warm， nutritional support， maintaining water and electrolyte and acid-base balance， blue light irradiation and severe patients were given liver protection， enzyme inducers； observation group was additionally given Yinzhihuang oral liquid 10 ml， twice a day. The treatment course was 7 d. Clinical efficacy， and serum total bilirubin （TBIL） level before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）. After treatment， TBIL level in 2 groups was significantly lower than before and gradually decreased with time， and observation group was lower than control group， the differences were statistically significant（P＜0.05）. The incidence of adverse reactions of 2 groups was no statistically significant（P＞0.05）. CONCLUSIONS： Based on the conventional treatment， Yinzhihuang oral liquid can be used in the adjuvant treatment of neonatal breast-feeding faundice， with good efficacy and good safety.