OBJECTIVE： To investigate the characteristics and regulations of antibacterials-induced adverse drug reactions （ADR） in our hospital， and to provide reference for promoting rational drug use. METHODS： 233 patients with antibacterials-induced ADR in our hospital from Oct. 2013 to Jun. 2015 were selected and analyzed statistically according to patient’s age and gender， route of administration， the type of antibacterials， occurrence time， organs/systems involved in ADR， etc. RESULTS： There were a large number of ADR in patients age ≤18 and ≥70 years， accounting for 19.3％ and 18.5％； the male was more than the female； the incidence of ADR induced by intravenous route was the highest， accounting for 94.0％. Most of ADR was caused by cephalosporins， accounting for 33.9％； ADR often occurred within 1 d after medication， accounting for 63.9％； lesion of skin and its appendants injury was main ADR， accounting for 39.3％. CONCLUSIONS： Adhere to the “clear indications”， a detailed inquiry about allergy history before drug use， right dose， suitable route of administration and course， and timely ADR disposal can reduce the damage caused by ADR.