OBJECTIVE：To provide reference for implementing pharmaceutical care for secondary prevention of patients with myocardial infarction and improving medication compliance by clinical pharmacist. METHODS：A questionnaire survey was conducted for 200 secondary prevention patients with myocardial infarction in our hospital，and divided into good medication compliance group and poor medication compliance group by Morisky-Green（MG）standard scoring evaluation， and the reasons affecting the medication compliance were statistically analyzed. RESULTS：Totally 200 questionnaires were sent out，200 were effectively received with effective recovery of 100％. 137 patients showed good medication compliance and 62 patients showed poor medication compliance，there were statistically significant differences in the age，monthly income，whether there was a medical insurance or not，whether they live alone or not and whether they had more than 4 oral drugs between 2 groups（P＜0.05）. The reasons of poor medication compliance were forgetting to take the medicine，too many kinds of medicine，too expensive to afford the medicine， lacking the knowledge of the disease and poor medication guide. CONCLUSIONS：The poor medication compliance of patients with secondary prevention of myocardial infarction is closely related with elder age，low income，no medical insurance，living alone，and taking more than 4 kinds of medicine. Clinical pharmacists should play their professional expertise，repeatedly supervise patients’medication compliance and finally improve the efficacy and patients’quality of life.