OBJECTIVE： To observe the effects of Xiaoyaosan combined with psychological intervention on hormone levels of college entrance examination girls with irregular menstruation. METHODS： 52 college entrance examination girls with irregular menstruation were randomly divided into control group and observation group with 26 cases in each group. Control group was given Xiaoyaosan 360 ml， bid； observation group was additionally given psychological intervention on the basis of treatment control group. 2 groups of patients were treated for 3 months. Before and after treatment， clinical efficacy， progesterone （P）， estradiol （E2）， luteinizing hormone （LH）， follicle stimulating hormone （FSH） and prolactin （PRL） were observed in treatment groups， and then compared with control group. RESULTS： The total effective rate of treatment observation group was significantly higher than that of treatment control group （96.15％ vs. 84.62％）， with statistical significance （P＜0.05）. Before treatment and after treatment， compared with control group the levels of P， E2， LH，FSH and PRL in two groups were lower ，with not statistical significance （P＞0.05）； after treatment， the levels of P， E2， LH and FSH in two groups increased significantly， but PRL level decreased significantly， there was statistical significance between before treatment and after treatment （P＜0.01）. CONCLUSIONS： The pituitary can't excrete enough FSH， LH， E2， P， which is the main cause of irregular menstruation in college entrance examination girls. Xiaoyaosan can effectively treat this kind of irregular menstruation by adjusting the functions of  the hypothalamic-pituitary-ovarian axis， and adjunctive therapy of psychological intervention can increase curative effect.