OBJECTIVE：To observe the effects of Tanshinone ⅡA sulfonic acid sodium injection on blood supply and blood rheology of patients with central retinal vein occlusion ）CRVO）. METHODS：92 CRVO patients were selected and randomly divided into control group and trial group with 46 cases in each group. Control group was given routine treatment of laser photocoagulation； trial group was additionally given Tanshinone ⅡA sulfonic acid sodium injection 80 mg added into 0.9％ Sodium chloride injection 150 ml，ivgtt，qd. A treatment course of 2 groups lasted for 7 days，and both received 4 courses of treatment. The hemodynamics and hemorheology of central retinal artery（CRA）were recorded in 2 groups before and after treatment. The fluorescence angiography（ FFA）and optical coherence tomography（OCT）of 2 groups were also observed. RESULTS：Before treatment，there was no statistically significant difference in Vmax，Vmin and RI of CRA between 2 groups（P＞0.05）；after treatment，Vmax，Vmin and RI of CRA in 2 groups were improved significantly，the trial group was better than control group，with statistical significance（P＜0.05）. After treatment，whole blood high shear viscosity，whole blood low shear viscosity，plasma specific viscosity and fibrinogen of trial group were significantly lower than those of control group，and FFA and OCT of trial group were better than those of control group， with statistical significance（P＜0.05）. CONCLUSIONS：Tanshinone ⅡA sulfonic acid sodium injection can obviously improve hemodynamics and hemorheology of CRVO and blood supply and vision of lateral eye.