OBJECTIVE： To provide reference for rational use of narcotic drugs and category Ⅰ psychotropic drugs. METHODS： The utilization of narcotic drugs and category Ⅰ psychotropic drugs in clinical wards of Zhengzhou People’s Hospital during Jan.-Dec. in 2014 was analyzed statistically in respects of drug types， department distribution medication purpose， DDDs， DDC， DUI， etc. RESULTS： A total of 16 kinds of narcotic drugs and one kind of category Ⅰ psychotropic drugs were used in 28 981 prescriptions of narcotic drugs and category Ⅰ psychotropic drugs in our hospital in 2014； A total of 16 kinds of narcotic drugs and one categery Ⅰ psychotropic drugs were used， narcotic drugs mainly included Sufentanil citrate injection （7 816 prescriptions） and Fentanyl citrate injection （5 104 prescriptions）， and category Ⅰ psychotropic drugs mainly was Ketamine hydrochloride injection （190 prescriptions）. Narcotic drugs and category Ⅰ psychotropic drugs were mainly used in anesthesia department， pain department and medical oncology department. Main purpose of narcotic drugs and category Ⅰ psychotropic drugs were intraoperative anesthesia， cancer pain and postoperative analgesia. Top 3 drugs in the list of DDDs were Sufentanil citrate injection， Fentanyl citrate injection （0.1 mg） and Remifentanil for injection. CONCLUSIONS： The utilization of narcotics and category Ⅰ psychotropic drugs are generally rational in the hospital； the doctors can grasp the indication and medication principle， and use drugs rationally according to disease condition.