OBJECTIVE：To explore the new method for clinical pharmacists training，and provide reference for improving the quality of clinical pharmacists training. METHODS：Based on the full-awareness of Definition and characteristics of stage-progressive learning（SPL）and problem-based learning（PBL）teaching method，SPL-PBL teaching method was used in the teaching of theoretical and clinical practice in the process of students training in clinical pharmacist training base. The teaching course of theoretical knowledge was mainly SPL in first half and PBL in another half. While in the clinical practice teaching of ward rounds，checking doctor’s advice，participation in the development of treatment programs and case discussion，PBL was mainly used interspersed by SPL；SPL was mainly in inquiry，pharmaceutical care and medication education interspersed by PBL. RESULTS：SPL-PBL teaching method had not only effectively aroused the enthusiasm of the students’learning，enhanced the sense of responsibility and improved their clinical professional knowledge and practice ability，but also strengthened the cultivation of students communication ability，document retrieval ability，writing communication ability and self-learning ability（“four abilities”）to make students more quickly into the role and improve their subjective initiative. CONCLUSIONS：Practice has proved that the SPL-PBL teaching method not only gives consideratin to the inndividual differences among studengts，but also mobilizes the enthusiam，and not only gives consideration to the teaching about basic theoretical knowledge，but also strengthens the training for clinical thingkig and“four abilities”， wich can be used for the clinical pharmacists training. Meanwhile，SPL has expanded the aplication surface of PBL beacuse that SPL has reduced the requirements of PBL for overall qulity. However，it needs to be improved because of the short time application.