OBJECTIVE： To provide reference for rational drug use in the clinic. METHODS： By retrospective investigation， antibiotic use density （AUD） and sensitivity rates of Acinetobacter baumannii to commonly used antibiotics in the inpatients were analyzed statistically in our hospital during 2010-2014， and the relationship between AUD and drug resistance of A. baumannii were analyzed with Pearson and Spearman method. RESULTS： 2 537 strains of A. baumannii were detected in clinical microbiological specimen of inpatients from our hospital during 2010-2014. The sensitivity rates of A. baumannii to meropenem and imipenem were negatively correlated to AUD （r＝0.990，0.930，P＜0.05）. The sensitivity rate of A. baumannii to trimethoprim-sulfamethoxazole， ciprofloxacin， minocycline， piperacillin-tazobactam， cefepime， cefoperazone-sulbactam， ceftazidime and levofloxacin were not correlated to AUD.  CONCLUSIONS： The use of carbopenems is an important factor to drug resistance of A. baumannii.