OBJECTIVE： To provide basis for the reasonable use of imipenem. METHODS： Referring to the methods to establish DUE criteria， by literature study and expert consultation， DUE criteria was established and questionnaire was designed to collect the data of  imipenem use， in order to evaluate the use of imipenem. RESULTS： Established DUE criteria contained medication indications， medication process and treatment results. Unreasonable use of imipenem in our hospital was found in fields of liver/renal function test， drug use， treatment course and ADR monitoring. CONCLUSIONS： The established DUE criteria of imipenem shows strong practicability， and provide reference for the work development of clinical pharmacists.