OBJECTIVE：To explore risk factors for the death in HIV/AIDS patients suffering from myelosuppression during highly active antiretroviral therapy（HAART）treatment. METHODS：The historical cohort study method was used to choose 735 inpatients from Nanning Forth People’s Hospital during Jan. 2011 to Jul. 2015. Univariate and multivariate Logistic regression analysis were used to show the risk factors for the death. RESULTS：Of 735 cases，there were 648 survival cases and 87 dead cases， with mortality of 11.8％. Univariate Logistic analysis showed that：male，elder，higher total bilirubin，lower creatinine clearance， lower CD4+T cell count in baseline，combined more opportunistic infection，combined more myelosuppressive drugs，thrombocytopenia， lower hemoglobin were the risk factors for the death of HIV patients with myelosuppression in HARRT treatment，while route of HIV infection，HAART treatment A including Zidovudine，weight were the protective factors. Multivariate Logistic regression analysis showed male，elder，higher total bilirubin，lower creatinine clearance，lower CD4+ T cell count in baseline，combined more opportunistic infection，combined more myelosuppressive drugs，thrombocytopenia，lower hemoglobin were the risk factors for the death of HIV patients with myelosuppression in HARRT treatment too. CONCLUSIONS：Pertinence treatment and control methods for HIV/AIDS with myelosuppression in HARRT treatment should be taken to reduce the mortality in the future．