OBJECTIVE：To observe therapeutic efficacy of dexmedetomidine combined with propofol for sepsis infection deliration in patients underwent continuous intravenous blood replacement，and to study pharmacokinetic study. METHODS：60 patients with sepsis infection deliration underwent continuous intravenous blood replacement were selected and randomly divided into observation group and control group with 30 cases in each group. Control group was given propofol 0.5 mg/kg，and observation group given dexmedetomidine and propofol. Therapeutic efficacy of 2 groups were analyzed comparatively，and pharmacokinetic parameters of propofol were studied. RESULTS：The pharmacokinetic parameters of propofol as elimination half-life period （t1/2 β），slow distribution half-life period（t1/2 α）were shorter than literature reference value，with statistical significance（P＜ 0.05），while the distribution rate constants（K21，K13，K10），the central compartment volume of distribution（VC），systemic clearance（ CL），rapid distribution half-life period（t1/2pi）had no statistical significance，compared with literature reference value（P＞ 0.05）. After treatment，ICDSC score of 2 groups were decreased significantly，with statistical significance（P＜0.05），while the observation group was significantly higher than the control group，with no statistical significance before and after treatment（P＞ 0.05）；the average hospital stay of observation group was significantly shorter than that of control group，with statistical significance（ χ2＝6.263 4，P＝0.000）；the incidence of ADR in control group was significantly higher than the observation group，with statistical significance（P＜0.05）. CONCLUSIONS：Dexmedetomidine combined with propofol have good effect on sepsis infection deliration in patients underwent continuous intravenous blood replacement，and can reduce the length of hospital stay and the incidence of ADR.