OBJECTIVE：To obverse the efficacy and safety of tolynicate and napthylacetic acid and atorvastation combined with Danshen injection in the treatment of alcoholic hyperlipemia syndrome. METHODS：21 patients with alcoholic hyperlipemia syndrome were enrolled. All patients were given maintaining acid-base balance，oxygen inhalation and other conventional treatment. Based on it，they were orally given 75 mg Tolynicate and napthylacetic acid tablet，3 times a day+20 mg Atorvastatin calcium tablet， once a day+4 ml Compound danshen injection，adding into 150 ml 5％ Glucose injection by intravenous infusion，once a day. The treatment course for both groups was 30 d. Clinical efficacy，ALT，AST，TBIL，TC，TG，RBC and Hb before and after 6， 12，18，24 and 30 d，and incidence of adverse reactions were observed. RESULTS：After treatment，the total effective rate was 95.3％ and incidence of adverse reactions was 28.5％. The ALT，AST and TBIL after 6，12，18，24 and 30 h and TC and TG after 18，24 and 30 h were significantly lower than before and gradually decreased by time；RBC and Hb after 12，18，24 and 30 h were significantly higher than before and gradually increased by time，the differences were statistically significant（P＜0.05）. CONCLUSIONS： tolynicate and napthylacetic acid and atorvastation combined with Danshen injection is effective in the treatment of alcoholic hyperlipemia syndrome，with good safety.