OBJECTIVE：To observe the efficacy and safety of low-dose ropivacaine combined with sufentanil in the upper limb anesthesia. METHODS：100 patients with upper limb anesthesia were randomly divided into control group and test group. Control group was intravenously injected 20 ml 0.5％ ropivacaine；test group was intravenously injected 20 ml 0.375％ ropivacaine +10 μg sufentanil. The anesthesia effect，disappearance time of pain，duration of analgesia，and pain visual analogue（VAS）score before anesthesia（T0），5 min（T1），15 min（T2）and 30 min（T3）after anesthetic block，and 4 h（T4）and 8 h（T5）after surgery，and incidence of adverse reactions in 2 groups were observed. RESULTS：VAS scores at T1-T5 in test group and T2-T4 in control group were significantly lower than T0，test group was lower than control group at T1，T2 and T5，the differences were statistically significant（ P＜0.05）. The total effective rate of anesthesia in test group was significantly higher than control group，disappearance time of pain was significantly shorter than control group，duration of analgesia was significantly longer than control group，incidence of adverse reactions was significantly lower than control group，the differences were statistically significant（P＜0.05）. CONCLUSIONS： Both the efficacy and safety of low-dose ropivacaine combined with sufentanil in the upper limb anesthesia are good.